Covid19 Mind Map -> Data Dump - Thoughts on Innovation and Healthcare

This is a data dump of my collection of information around Covid19. A better way to view this information would be through the Mind Map on Mindmeister. Updated on 5/31/2020

Representative Image

Plain text with heirarchy and Links - It may get ugly beyond this point :) Some links may be missing

SARS2 / Covid19 All + All -

SARS2 / Covid19

+ - Idea Hacking
- https://docs.google.com/document/d/1rVz-GPtF2ek-8V2sZcZPPfL6ocXqtCUEWFEwiDp-7_Y/edit?usp=drivesdk
- + - MUSC Mask w/ HEPA
  - https://web.musc.edu/innovation/covid-19-innovation
- + - Czech Face Shield Design
  - https://www.prusa3d.com/covid19/
+ - Diagnosis / Management
- + - Clinical
  - + - Symptoms
    - + - Disease Progression
      - + - Comorbidities
        
        “Meta-Analyses Reveal Who Should Be More Cautious of COVID-19” by Shin Jie Yong https://link.medium.com/WrxQrohTH5
    - + - Cardiac
      - https://khn.org/news/mysterious-heart-damage-not-just-lung-troubles-befalling-covid-19-patients/
    - + - Expanded Case Definition
      - The Washington Post: CDC confirms six coronavirus symptoms showing up in patients over and over. https://www.washingtonpost.com/health/2020/04/27/six-new-coronavirus-symptoms/
  - + - Where all do we have ACE2 Receptors?
    - ~ Angiotensin-converting enzyme 2 - Wikipedia
    - Lungs
    - Heart
    - Arteries
    - Intestines
    - Where else?
    - + - Inhibition
      - rhACE2?
    - ~ How does coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes
  - + - Signs
    - Red itchy eyes / conjunctivitis
  - + - Tests / Biomarkers of severe disease
    - https://pubmed.ncbi.nlm.nih.gov/32286245/
  - + - Pathophysiology
    - URTI
    - + - LRTI
      - CT Lung https://www.ncbi.nlm.nih.gov/pubmed/?term=32053470
      - + - Type L / Type H Pneumonia?
        
        https://link.springer.com/article/10.1007/s00134-020-06033-2
        
        Fluid management issues
      - + - CPAP vs BiPAP (information)
        
        ~ CPAP vs BiPAP - Non-Invasive Ventilation EXPLAINED
      - + - Breathing mechanics
        
        ~ Respiratory | Mechanics of Breathing: Pressure Changes | Part 1
    - + - GI
      - https://www.thelancet.com/journals/langas/article/PIIS2468-1253(20)30083-2/fulltext
    - + - Cardiac / Lung / Kidney
      - https://www.ahajournals.org/doi/10.1161/JAHA.120.016219
    - ARDS
    - + - Atypical ARDS?
      - ~ https://www.youtube.com/watch?v=U5cvPwh_vtM&t=8s
      - + - Hypoxemia
        
        ~ COVID19 Respiratory Management
        
        + - Consider Erythropoetin?
        
        https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25839
        
        Blood Transfusions?
        
        Artificial O2 carriers?
        
        + - High Flow O2 Therapy
        
        ~ [Clinical experience of high-flow nasal cannula oxygen therapy in severe corona virus disease 2019 (COVID-19) patients]. - PubMed - NCBI
        Needs lot of 02 - Bottle neck
        
        + - “Inflammatory Cutoff”
        
        hsCRP?
        
        d-Dimer?
        
        Who needs invasive ventilation vs supplemental O2 (High flow)?
      - See also HCQ Bubble
      - + - Different phenotypes - Italian experience
        
        https://link.springer.com/article/10.1007/s00134-020-06033-2
    - + - Coagulopathies / DIC?
      - ~ Coagulation Abnormalities in COVID 19 Patients
      - + - Why?
        
        Cytokine Storm?
        
        ACE2 mediated Arterial Damage?
        
        Selective Damage / Activation of Coagulation pathway?
        
        2.dary to selective Hb damage / binding?
    - + - Microangiopathy in the lung
      - https://www.nejm.org/doi/full/10.1056/NEJMoa2015432?query=C19&cid=DM92296_Catalyst_Subscriber&bid=201860269
    - + - Derm
      - + - Covid Toes
        
        https://www.medscape.com/viewarticle/930286
    - + - ACE2 Mediated Vascoconstriction?
      - ~ A Theoretical Model of the Pathophysiology of COVID-19 with Farid Jalali
  - + - Risk Factors
    - https://pubmed.ncbi.nlm.nih.gov/32232218/
    - Comorbidities
  - + - ~ COVID-19 | Corona Virus: Epidemiology, Pathophysiology, Diagnostics
    - As of March 15th
  - + - NEJM
    - https://www.nejm.org/coronavirus
    - + - Case Study - Long Term Health Care Facility - Washington State
      - https://www.nejm.org/doi/full/10.1056/NEJMoa2005412?cid=DM89287_Catalyst_COVID-19_Newsletter&bid=174243764
  - Lancet
  - + - Predisposition to severe disease symptoms
    - https://jamanetwork.com/journals/jamacardiology/fullarticle/2763845
    - + - Inflammation as a modifier?
      - Any correlations with hs-CRP?
  - + - Social Determinants
    - https://www.beckershospitalreview.com/data-analytics/ucsf-launches-dashboard-to-track-how-social-determinants-affect-population-health.html
      + - https://www.healthaffairs.org/doi/full/10.1377/hlthaff.2020.00598?utm_campaign=HASU+5-24-20&utm_medium=email&utm_content=COVID-19%3A+Disparities+In+Outcomes%2C+Primary+Care%2C+Remdesivir%3B+ACA+Round-Up%3B+Health+Insurance+Surcharges+For+Tobacco+Use%3B+Reimagining+Involuntary+Commitment&utm_source=Newsletter
      - Why are people of color disproportionately susceptible to severer outcomes?
- + - Testing
  - + - NAAT
    - + - RT-PCR
      - + - N Segment
        
        CDC
      - Other segments
      - https://youtu.be/C1t3SoR8fwg
    - IIT Probe less Dx - https://www.linkedin.com/posts/activity-6647392190601539584-zv0l - POC
  - + - Serological
    - IgM
    - IgG
  - + - ALT predictor of severe lung complications?
    - https://www.france24.com/en/20200330-ai-tool-predicts-which-coronavirus-patients-get-deadly-wet-lung
    - https://en.wikipedia.org/wiki/Alanine_transaminase
  - + - CRISPR
    - + - India
      - Feluda - https://theprint.in/science/satyajit-rays-feluda-will-soon-detect-coronavirus-in-minutes-thanks-to-csir-scientists/404057/
  - + - Rapid Biosensor S Korea
    - https://pubs.acs.org/doi/10.1021/acsnano.0c02823
~ Clinical Characteristics, Comorbidities, and Outcomes Among Patients With COVID-19 Hospitalized in the NYC Area
+ - Data Sources
- + - JHU
  - https://coronavirus.jhu.edu/
  - + - Github
    - https://github.com/CSSEGISandData/COVID-19
- + - FDA Covid FAQs
  - ~ Coronavirus Disease 2019 (COVID-19) Frequently Asked Questions
- + - The Covid Handbook - China
  - PDF
- + - Prevalence
  - + - NYC
    - + - https://www.nejm.org/doi/full/10.1056/NEJMc2009316?fbclid=IwAR1JU20xBGOuad0UDREUjGb1Kpj1VQ0ypbkwL_GheeFr15rvREpxEwuSBqg
      - “Of the 211 women without symptoms, all were afebrile on admission. Nasopharyngeal swabs were obtained from 210 of the 211 women (99.5%) who did not have symptoms of Covid-19; of these women, 29 (13.7%) were positive for SARS-CoV-2. Thus, 29 of the 33 patients who were positive for SARS-CoV-2 at admission (87.9%) had no symptoms of Covid-19 at presentation.”
  - + - Santa Clara County
    - + - ~ COVID-19 Antibody Seroprevalence in Santa Clara County, California
      - “Under the three scenarios for test performance characteristics, the population prevalence of COVID-19 in Santa Clara ranged from 2.49% (95CI 1.80-3.17%) to 4.16% (2.58-5.70%).”
- + - Napkin iFR
  - ~ Preliminary CFR - Covid
- + - California
  - ~ https://public.tableau.com/views/COVID-19PublicDashboard/Covid-19Public?:embed=y&:display_count=no&:showVizHome=no
- + - YouTube
  - ~ covid - YouTube
- + - Case Definition CDC April 14th
  - ~ Coronavirus Disease 2019 (COVID-19) in the U.S.
  - To include Probable Cases and Probable Deaths
  - + - CDC Cases in the US
    - ~ Coronavirus Disease 2019 (COVID-19) in the U.S.
- + - R Packages and Shiny Apps
  - + - https://towardsdatascience.com/top-5-r-resources-on-covid-19-coronavirus-1d4c8df6d85f
    - + - Covid19 DataHub
      - ~ covid19datahub/COVID19
- + - CDC
  - + - Scenario Planning
    - https://www.cdc.gov/coronavirus/2019-ncov/hcp/planning-scenarios.html
+ - Epidemiological Concepts
- + - R0 (Reproductive Ratio)
  - ~ Basic Reproduction Number, R0
- Stages of Spread
- + - SIR Model
  - https://youtu.be/Qrp40ck3WpI
  - https://youtu.be/uSLFudKBnBI
+ - Legend
- Anecdotal
- Re-purposed Approaches
- Hypotheses
- Adjuvants
- In development
- Very Important
+ - Surveillance
- + - Waste Water
  - https://www.bloomberg.com/news/articles/2020-03-31/coronavirus-in-sewage-portended-covid-19-outbreak-in-dutch-city
- + - Recurrence?
  - ~ Can you get re-infected with coronavirus?
- Santa Clara Study
- NY maternity Study
- India’s Delhi Food Worker Study
- NY City Surveillance
+ - Questions / Hypotheses
- Is genetic diversity more resilient to developing severe forms of covid19 at a population level?
  Virus particles are small - they replicate fast - as part of replication they damage cells - they then enter adjacent cells - they basically over time will make their own access route. It seems some strains replicate faster than other ones, and so they will be the ones I’m guessing that are causing more of the non lung / non intestinal issues?
  Background inflammation relevant? hsCRP?
  + - Nicotine / Smoking?
  - https://theprint.in/health/nicotine-patch-test-on-covid-patients-healthcare-workers-to-see-if-smokers-are-protected/413513/
+ - India
- + - The Bhilwara Model
  - https://www.mohfw.gov.in/pdf/3ContainmentPlanforLargeOutbreaksofCOVID19Final.pdf
- + - National Covid Trajectory
  - ~ National Covid Trajectory - India
How to Protect MeS Individuals?
+ - Virus Morphology
- + - Mutation
  - https://youtu.be/FYPZHA-UjUY
  - + - Antigenic Shift - Influenza
    - https://youtu.be/tMTl3gU0mFc
  - + - Tracking the different strains
    - https://nextstrain.org/
  - + - India
    - ~ No need to panic, COVID-19 is something we can easily conquer: Padma Bhushan Dr D Nageshwar Reddy
  - + - Super virulent strains?
    - https://www.scmp.com/news/china/science/article/3080771/coronavirus-mutations-affect-deadliness-strains-chinese-study
- + - Replication Cycle
  - https://youtu.be/zvuYJTL90J8
- + - Coronaviruses
  - ~ Coronaviruses 101: Focus on Molecular Virology
- + - Seasonality?
  - https://www.cidrap.umn.edu/news-perspective/2020/04/experts-covid-19-pandemic-unlikely-ebb-weather-warms
- + - ReplicationKinetics
  - ~ Kinetic Modeling of Virus Growth in Cells
+ - Equipment
- + - PPE
  - + - Facial Masks
    - + - Reusable
      - + - Elastomeric
        
        https://www.ncbi.nlm.nih.gov/books/NBK540078/
      - + - Non soiled N95
        
        https://www.n95decon.org/publications
    - + - Disposable
      - Surgical
      - N95
  - Shields
  - Gowns
  - Gloves
  - Booties
  - Suits
  - + - PAPR - Another bottle neck
    - A must for invasive ventilation?
  - + - Suppliers - PPE / Serology Tests
    - + - Global - Sourced From China
      - + - Prices as of March 27th
        
        PDF
    - + - Local India PPE / Sanitizer
      - Rnexports@hotmail.com
- Ventillators
- Plasmaphaeresis
- + - CPAP
  - + - Italy
    - + - CPAP with Helmets
      - https://www.uchicagomedicine.org/forefront/patient-care-articles/helmet-based-ventilation-is-superior-to-face-mask-for-patients-with-respiratory-distress
  - + - What is CPAP?
    - ~ What’s the Difference Between a CPAP, APAP, and BiPAP Machine?
+ - Prevention
- + - Social distancing
  - Self imposed
  - State imposed
- + - Prevention Strategies
  - + - Disinfection
    - Alcohol Based
    - + - Hydrogen Peroxide
      - + - Vapor phase
        
        + - The Verge: FDA approves Battelle’s process to decontaminate N95 face masks. https://www.theverge.com/2020/3/29/21198715/fda-approves-battelles-decontaminate-n95-face-masks-coronavirus
        
        ~ Coronavirus: FDA provides full OK for Battelle mask-sterilizing technology
        
        + - Steris - FDA Approval
        
        ~ Coronavirus (COVID-19) Update: FDA Issues Second Emergency Use Authorization to Decontaminate N95 Respirators
    - + - Chlorine Based
      - Na Hypochlorite
    - + - Non contact
      - + - UV light
        
        + - UV C
        
        https://www.researchgate.net/publication/339887436_2020_COVID-19_Coronavirus_Ultraviolet_Susceptibility
        
        + - UV A
        
        https://drive.google.com/open?id=1UL35fCvDzwfaUc-LnQJRj4r-64nZqzG7hbiuQWFh4-M
      - + - Negative Ions
        
        https://theprint.in/science/govt-funds-start-up-to-produce-device-that-reduces-presence-of-coronavirus-in-closed-space/391531/
    - + - EPA - Surface Disinfectants - List N
      - ~ List N: Disinfectants for Use Against SARS-CoV-2 | US EPA
  - + - Boost Immunity
    - + - BCG vaccine
      - https://www.sciencemag.org/news/2020/03/can-century-old-tb-vaccine-steel-immune-system-against-new-coronavirus
        Pharmaceutical Technology: BCG vaccination may induce heterologous immunity and protect against Covid-19. https://www.pharmaceutical-technology.com/comment/bcg-vaccination-covid-19/
    - Convalescent Plasma
    - Nutrition / Sleep / Exercise
    - + - Vitamin D ?
  - Personal Hygiene
  - + - Contact Tracing
    - https://www.npr.org/sections/health-shots/2020/04/21/840539685/cdc-to-fund-650-health-experts-to-help-states-trace-stop-covid-19
- + - Immunization
  - + - Vaccine
    - + - J & J
      - https://www.forbes.com/sites/thomasbrewster/2020/03/30/the-us-just-signed-a-450-million-coronavirus-vaccine-contract-with-johnson--johnson/
      + - https://www.nih.gov/news-events/news-releases/nih-clinical-trial-investigational-vaccine-covid-19-begins
      - Phase 1 Kaiser
      + - PittCoVacc
      - https://www.independent.co.uk/news/science/coronavirus-vaccine-pittsburgh-university-lancet-study-covid-pandemic-a9442536.html
      + - Chadox1
      - https://www.vaccitech.co.uk/technology/
      - http://www.ox.ac.uk/news/2020-04-23-oxford-covid-19-vaccine-begins-human-trial-stage#
      + - mRNA
      - + - Moderna
        
        ~ A US vaccine races ahead & creates science-billionaires
  - + - Convalescent Plasma
    - http://www.fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/investigational-covid-19-convalescent-plasma-emergency-inds
      JHU - Immunization of Healthcare Workers - http://foxbaltimore.com/news/coronavirus/fda-approves-trial-for-coronavirus-therapy-at-johns-hopkins-university
  - + - What is immunity
    - ~ Immune System: Innate and Adaptive Immunity Explained
- + - LAV
  - https://theprint.in/health/in-a-first-india-us-pharma-majors-join-hands-to-develop-covid-19-vaccine/397334/
- + - Nutrition - As anti inflammatory
  - + - https://www.mdpi.com/2072-6643/12/5/1466/htm
    - Vit D / C + Zinc + Fiber
- + - Seroconversion = Immunity?
  - https://www.medrxiv.org/content/10.1101/2020.05.19.20101832v2
+ - Treatment
- + - Symptomatic
  - + - ARDS or Atypical ARDS
    - + - Ventilators
      - + - Low cost ventilators
        
        https://youtu.be/IgAR4yWDsg0
        MIT open source - https://scitechdaily.com/mit-posts-free-plans-online-for-an-emergency-ventilator-that-can-be-built-for-100/
      - + - General Motors
        
        https://www.bloomberg.com/news/articles/2020-03-30/inside-gm-s-four-week-sprint-to-build-emergency-ventilators
    - + - O2 hoods
      - https://erj.ersjournals.com/content/early/2020/04/16/13993003.01017-2020
  - GI
  - Non-ARDS
- + - Pharmacological
  - + - Anti-virals
    - + - Favipiravir
      - https://fortune.com/2020/03/28/coronavirus-treatment-drug-antiviral-favipiravir-avigan-fujifilm/
      - Link to Chinese study?
    - + - Remdesivir
      - https://www.fiercebiotech.com/biotech/gilead-supersizes-remdesivir-trials-changes-primary-endpoint
      - + - SoC according to Fauci as of 4/29
        
        Link so n = 1009 study?
    - + - Lopinavir? Probably Not?
      - https://theprint.in/health/hiv-drug-combo-touted-as-a-promising-covid-19-treatment-fails-clinical-trial/405959/
  - + - HCQ / Chloroquine
    - FDA Emergency Authorization - https://www.politico.com/news/2020/03/29/fda-emergency-authorization-anti-malaria-drug-155095
      + - Haem metabolism
      - https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173
      + - IHU - Mediterranean Infection
      - ~ Pré-Prints IHU – IHU
      + - VA Study - Contraindicated in those over 70?
      - https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v1.full.pdf
  - + - Others
    - Azithromycin
  - + - ACE2 Receptor Blockers?
    - http://www.infectioncontroltoday.com/covid-19/evidence-continues-link-ace-inhibitors-severe-covid-19-symptoms
      How to treat those with hypertension?
      ~ Jacob Glanville on LinkedIn: #COVID19 #therapeutic #neutralizing | 103 comments
      + - ACE2 Receptor
      - ~ https://www.genecards.org/cgi-bin/carddisp.pl?gene=AGTR1&keywords=ACE2,Receptor
  - + - hsp90 inhibition?
    - ~ Drug Repositioning Suggests a Role for the Heat Shock Protein 90 Inhibitor Geldanamycin in Treating COVID-19 Infection
      + - What else inhibits hsp90?
      - + - curcumin
        
        + - ~ Curcumin inhibits human cytomegalovirus by downregulating heat shock protein 90
        
        https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1745-7254.2006.00326.x
        
        + - Also synergistic
        
        https://link.springer.com/article/10.1007/s00018-009-0233-x
  - + - TMPRSS2 Inhibition
    - https://www.dpz.eu/en/home/single-view/news/die-vermehrung-von-sars-coronavirus-2-im-menschen-verhindern.html
      + - Genetic Expression of ..
      - https://www.medrxiv.org/content/10.1101/2020.03.30.20047878v1.full.pdf
  - + - Anti-coagulants
    - https://www.eurekalert.org/pub_releases/2020-05/tmsh-btm050420.php
  - + - Ivermectin?
    - https://www.sciencedirect.com/science/article/pii/S0166354220302011
    - Ivermectin and Doxy being used in Bangladesh
- + - Immunological
  - + - Convalescent Plasma
    - http://www.fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/investigational-covid-19-convalescent-plasma-emergency-inds
      https://jamanetwork.com/journals/jama/fullarticle/2763983
      https://www.bizjournals.com/philadelphia/news/2020/04/06/montco-firm-forms-alliance-to-develop-coronavirus.html
      https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/donate-covid-19-plasma
      + - Michigan State Convalescent Plasma Project
      - ~ National COVID-19 Convalescent Plasma Project
      - + - Key Scientific Papers
        
        ~ Key Scientific Papers | National COVID-19 Convalescent Plasma Project
      + - FDA Recommendations
      - ~ Investigational COVID-19 Convalescent Plasma - Emergency INDs
  - + - Monoclonal Antibodies
    - https://www.npr.org/sections/health-shots/2020/03/26/822003826/how-monoclonal-antibodies-might-prove-useful-against-the-coronavirus
  - + - Immunomodulators
    - + - Sepsivac / India
      - ~ CSIR to test sepsis drug in asymptomatic Covid patients and those who have recovered
- + - Stem Cells?
  - + - Miomir’s LI Post
    - https://www.linkedin.com/posts/miomir-knezevic-5a79613_novel-approach-to-treating-terminal-stage-activity-6648598562789736450-nePZ
- + - Nutrition
  - + - Clinical Considerations
    - + - Pg 30 - Handbook of Covid-19 Prevention and Treatment, Zhejiang University School of Medicine.
      - Prevention of Regurgitation and Aspiration - Gastric residual volume and gastrointestinal function should be routinely evaluated. Appropriate enteral nutrition is recommended to be given as earlier as possible. Nasointestinal feeding and continuous nasogastric decompression are recommended. Enteral nutrition should be suspended and aspiration with 50 mL syringe be done before transfer. If no contraindication exists, a 30° semi-sitting position is recommended
        + - Fluid Management - Excessive fluid burden worsens hypoxemia in COVID-19 patients. To reduce pulmonary exudation and improve oxygenation, the amount of fluid should be strictly controlled while ensuring the patient’s perfusion.
        
        So Parenteral Nutrition is Contraindicated?
        
        + - GI Considerations
        
        + - Some COVID-19 patients have gastrointestinal symptoms (such as abdominal pain and diarrhea) due to direct viral infection of the intestinal mucosa or antiviral and anti-infective drugs. There have been reports that the intestinal micro ecological balance is broken in COVID-19 patients, manifesting a significant reduction of the intestinal probiotics such as lactobacillus and bifidobacterium. An intestinal microecological imbalance may lead to bacterial translocation and secondary infection, so it is important to maintain the balance of intestinal microecology by microecological modulator and nutritional support.
        
        + - GI Infection by nCov19 leads to worsening states over time due to spread of bacteria from the intestines.
        
        + - This requires microbiome support
        
        + - This prevents
        
        Unhealthy Gut Bacteria Populations hence preventing translocation.
        
        + - Diarrhea and fluid loss
        
        Prevents unnecessary movement of patients.
        
        Intestinal Atrophy
        
        + - The severe and critically ill COVID-19 patients who are in a state of severe stress are at high nutritional risks. Early evaluations of nutrition risk, gastrointestinal functions and aspiration risks, and timely enteral nutritional support are important to the patient’s prognosis.
        
        Is there a case study for this?
        + - Enteral nutrition pathway. Severe and critically ill patients often harbor acute gastrointestinal damages, manifested as abdominal distension, diarrhea, and gastroparesis.
        
        + - Oral feeding is preferred. The early intestinal nutrition can provide nutritional support, nourish intestines, improve intestinal mucosal barrier and intestinal immunity, and maintain intestinal microecology
        
        This prevents translocation of bacteria
        
        For patients with tracheal intubation, intestinal nutrition tube indwelling is recommended for post-pyloric feeding
        
        + - Selection of nutrient solution
        
        For patients with intestinal damage, predigested short peptide preparations, which are easy for intestinal absorption and utilization, are recommended
        For patients with good intestinal functions, whole-protein preparations with relatively high calories can be selected.
        For hyperglycemia patients, nutritional preparations which are beneficial to glycemic controlling are recommended
        
        + - Energy Considerations
        
        Energy supply. 25-30 kcal per kg body weight, the target protein content is 1.2-2.0 g/kg daily.
        
        + - Means of nutritional supply
        
        + - Pump infusion of nutrients can be used at a uniform speed, starting with a low dosage and gradually increasing.
        
        When possible, the nutrients can be heated before feeding to reduce intolerance
        
        + - Note: VBF May be better?
        
        Why in this particular condition?
        
        The elderly patients who are at high aspiration risks or patients with apparent abdominal distention can be supported by parenteral nutrition temporarily. It can be gradually replaced by independent diet or enteral nutrition after their condition improves
- + - WHO Solidarity Trial
  - https://www.sciencemag.org/news/2020/03/who-launches-global-megatrial-four-most-promising-coronavirus-treatments
+ - Italy
- + - Vo
  - https://www.medrxiv.org/content/10.1101/2020.04.17.20053157v1
+ - Models / Literature
- + - Italian SIDR Model
  - ~ Data-based analysis, modelling and forecasting of the COVID-19 outbreak
- + - DoD Model for information evolution
  - https://www.pnas.org/content/117/11/5664
- + - IHME
  - https://covid19.healthdata.org/united-states-of-america
+ - Patient Flow
- + - I’m having difficulty breathing
  - emergency.fyi
  - Kaiser
- + - I have symptoms
  - + - CDPH
    - ~ California Department of Public Health
- + - Monitor Pulse Ox Levels
  - + - Cutoff?
    - 90%?
    - 95%?
+ - Disaggregate News Reports
- https://theprint.in/health/pancreatitis-drug-trials-to-a-wastewater-test-for-tracking-virus-top-research-on-covid-19/391990/
+ - Milestones
- + - 4/30
  - Korea confirms reinfections aren’t taking place
  - + - Remdesivir becomes SoC in the US
    - Next step is Remdesivir + Monoclonal Antibodies

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